COMPOSITIONS AND METHODS FOR IMPROVED DETECTION AND CLASSIFICATION OF NEOPLASMS

摘要

A first aspect of the present invention is composition including at least two different specific binding members such as antibodies or active fragments thereof that specifically bind with at least two different transcription factors. A second aspect of the present invention is a method of diagnosing a neoplasm or malignancy or prognosing the course of a malignancy or treatment thereof including contacting at least one specific binding member that specifically bind with a transcription factor with a sample, and detecting the binding of said specific binding member with a transcription factor in said sample. A third aspect of the present invention is a method for identifying a test compound that modulates a neoplasm or malignancy including contacting a sample with at least one test compound, contacting said sample with at least one specific binding member that binds with at least one transcription factor, and detecting the binding of said at least one specific binding member with at least one transcription factor.