MCH ANTAGONISTS

摘要

Compounds of general formula (I), salts of the same, or prodrugs thereof are useful as antagonists against melanin concentrating hormone (MCH) wherein Ar<1> and Ar<2> are each an optionally substituted aromatic group; P and Q are each a divalent aliphatic hydrocarbon group which may contain ethereal oxygen or sulfur in the carbon chain and may be substituted; R<1> and R<3> are each (i) hydrogen, (ii) acyl, or (iii) optionally substituted hydrocarbyl; R<2> and R<4> are each (i) hydrogen, (ii) optionally substituted alkyl, or (iii) optionally substituted alkylcarbonyl; alternatively R<1> and R<2> or R<3> and R<4> together with the nitrogen atom adjacent thereto may form a monocyclic or fused nitrogenous heterocyclic group; and j is 0 or 1.