CASPASE INHIBITOR

摘要

The present invention relates to an isoxazoline derivative of formula (I), t he pharmaceutically acceptable salts, esters and stereochemically isomeric form s thereof, and the use of the derivative in inhibiting the activity of caspase s. The present invention also relates to a pharmaceutical composition for preventing inflammation and apotosis which comprises the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivativ e according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells ar e abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injure by hepatitis, sepsis, organ transplantation rejection reactio n and anti-inflammation.