Aminoacylases for acylation of alcohols and amines

摘要

A process for the acylation of racemic alcohols or amines or their cleavage by the aid of aminoacylases is described. Amines and alcohols can be acylated by aminoacylases. So far only amino acids and alcohols have proved to be suitable substrates. But alcohols are poorly transformed. Immobilised aminoacylases transform alcohols enantioselectively into esters to an extent that the reaction can be adopted on technical scale in an economically manner. Aminoacylases turnover amines accordingly.