发明名称 |
TRAMADOL CONTAINING RETARDED PHARMACEUTICAL COMPOSITIONS, HAVING STORAGE-STABILED RELEASE AND PROCESS FOR PRODUCING THEM |
摘要 |
Production of an orally administered retard preparation containing tramadol (I) (or its salt) involves forming a coating with an aqueous ethyl cellulose (EC) dispersion containing at least one lipophilic diester plasticizer (II) (derived from a 6-40C aliphatic or aromatic dicarboxylic acid and a 1-8C aliphatic alcohol) and drying the coating at the usual temperature. This gives a storage-stable release profile, and release is optionally accelerated (without affecting the stability of the profile) by tempering above 35 degrees C. An Independent claim is included for a preparation obtained by the process, having a coalescent EC coating. |
申请公布号 |
HU0000140(A3) |
申请公布日期 |
2001.03.28 |
申请号 |
HU20000000140 |
申请日期 |
2000.01.17 |
申请人 |
GRUENENTAL GMBH., AACHEN |
发明人 |
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分类号 |
A61K9/20;A61K9/22;A61K9/26;A61K9/36;A61K9/50;A61K9/52;A61K31/135;A61K31/137;A61K47/14;A61K47/38 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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