| 发明名称 |
GENE RECOMBINANT ANTIBODIES |
| 摘要 |
<p>The present invention relates to a gene recombinant antibody which specifically reacts with human VEGF receptor Flt-1. Also, the present invention relates to a gene recombinant anti-human VEGF receptor Flt-1 antibody having an activity which neutralizes human Flt-1. Furthermore, it provides a method, a diagnostic agent and a therapeutic agent for treating diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in chronic rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.</p> |
| 申请公布号 |
EP1086956(A1) |
申请公布日期 |
2001.03.28 |
| 申请号 |
EP19990921206 |
申请日期 |
1999.05.20 |
| 申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
SHITARA, KENYA;ITO, MIKITO;KAWADA, YOKO;NAKAMURA, KAZUYASU |
| 分类号 |
C07K16/28;C12N15/13;C12P21/08;G01N33/68;G01N33/74;(IPC1-7):C07K16/28;A61K39/395;G01N33/53;C07K16/46;C12N5/10;G01N33/577 |
主分类号 |
C07K16/28 |
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