| 发明名称 |
Bis-phosphonate confugates with alkylating moieties having antitumor activity |
| 摘要 |
The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
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| 申请公布号 |
US6207655(B1) |
申请公布日期 |
2001.03.27 |
| 申请号 |
US20000381701 |
申请日期 |
2000.01.13 |
| 申请人 |
NOVUSPHARMA S.P.A. |
发明人 |
LIVI VALERIA;SPINELLI SILVANO;CONTI MARCO;D'ALO' SIMONETTA;MENTA ERNESTO |
| 分类号 |
C07F9/38;C07F9/40;(IPC1-7):A61K31/19;A61K31/215;A61K31/66 |
主分类号 |
C07F9/38 |
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