| 发明名称 |
Tuberous sclerosis 2 gene and uses thereof |
| 摘要 |
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterised by widespread development of growths in many tissues and organs. A gene (TSC2) is identified on chromosome 16 which is mutated in TSC and which may behave as a tumour suppressor. Screening of actual or suspected TSC patients for normal or mutated TSC2 can be used for diagnostic purposes. TSC2 protein (tuberin) may be used to treat or prevent unrestrained cell division and/or tumour development in patients with or without TSC.
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| 申请公布号 |
US6207374(B1) |
申请公布日期 |
2001.03.27 |
| 申请号 |
US19980040738 |
申请日期 |
1998.03.18 |
| 申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
SAMPSON JULIAN R.;NELLIST MARK DAVID;BROOK-CARTER PHILLIP;MAHESHWAR MAGITHA;HALLEY DIRKJE JORIJNTE JOHANNA;JANSSEN LAMBERTUS ANTONIUS JACOBUS;HESSELING ARJENNE LIQUE WILHELMA;VAN DEN OUWELAND ANNA MARIA WILHELMINA;HARRIS PETER CHARLES;WARD CHRISTOPHER JAMES;BREUNING MARTIN HENDRIK;ROELFSEMA JEROEN HENDRIK |
| 分类号 |
G01N33/566;A61K31/70;A61K38/00;A61K39/395;A61K48/00;A61P13/02;A61P13/12;A61P15/00;A61P35/00;C07H21/02;C07H21/04;C07K14/46;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/68;C12R1/19;(IPC1-7):C12Q1/68;C12P19/34 |
主分类号 |
G01N33/566 |
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