| 摘要 |
PROBLEM TO BE SOLVED: To obtain a highly reactive compound in high purity by blowing gas into a reaction mixture containing a water-soluble compound, which is obtained by acting a biocatalyst on a substrate in an aqueous medium, in a bubbly state, and removing a specific amount of the formed foam layer to purify the reaction mixture. SOLUTION: Gas such as air or nitrogen is blown into a reaction mixture containing a water-soluble compound such as acrylamide, nicotinamide, 5- cyanovaleramide or S,S-ethylenediamine-N,N'-disuccinic acid aqueous solution, which is obtained by acting a biocatalyst such as immobilized microbial cells or immobilized enzyme on a substrate in an aqueous medium, in a bubbly state, and 0.1-100% of the formed foam layer is removed. Thus, the reaction mixture containing biocatalyst is purified. Further, the removed component is fine solids derives from the biocatalyst.
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