发明名称 |
Specific antibodies and antibody fragments |
摘要 |
The present invention relates to methods and products for immunotherapy resulting in the stimulation of T-cell proliferation. The products of the invention are peptides that bind to CTLA-4 and co-stimulate the proliferation of T-cells by inhibiting the binding of B7 to CTLA-4. Pharmaceutical compositions including such peptides are also provided. The invention further provides in vitro and in vivo therapeutic methods employing the peptides of the invention.
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申请公布号 |
US6207156(B1) |
申请公布日期 |
2001.03.27 |
申请号 |
US19980040953 |
申请日期 |
1998.03.18 |
申请人 |
BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
KUCHROO VIJAY K.;GREENFIELD EDWARD A. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;A61P37/04;C07K16/24;C07K16/28;C12N5/10;C12N5/20;(IPC1-7):A61K39/395;C12N5/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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