| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new SHD 1 protein which functions as a control molecule of the differentiation or activation of centroembryonic B cell and comprises a specific amino acid sequence-containing SHD 1 protein of which the antibody is useful in the purification and detection of SHD 1 or the inhibition and treatment or the like for autoimmune diseases. SOLUTION: This SHD 1 protein is the new SHD 1 protein comprising the amino acid sequence represented by the formula and is expressed in the nucleus to function as the control molecule for controlling the differentiation or activation of centroenbryonic B cell by controlling the transport of cytochrome c or ATP into the cell. The antibody against this SHD 1 protein is usable for purifying or detecting the SHD 1 and is useful in the elucidation of the function, e.g. expression or the like, of the SHD 1, the control of the function of the B cell or the inhibition, treatment or examination of autoimmune diseases. This SHD 1 protein is obtained by using a mouse cDNA library as a template DNA, carrying out PCR using the partial sequence of SHD 1 gene as a primer, combining the resultant cDNA encoding the SHD 1 with a plasmid or the like to transduce into the host cell and cultivating the resultant transformant. |
