INJECTION AND INJECTION KIT CONTAINING OMEPRAZOLE AND ITS ANALOGS

摘要

An injection comprising a 2-[(2-pyridyl)methylsulfinyl]-benzimidazole compou nd or a salt thereof having antiulcer activity and an aqueous solvent added with no nonaqueous solvent, wherein the pH of t he injection is not less than 9.5 and not more than 11.5, and an injection kit comprising the following (a) and (b), wherein (a) and (b) are adjusted such that the pH upon dissolution of (a) in (b) is 9.5 - 11.5: (a): a lyophilized product of an alkaline aqueo us solution of a 2-[(2-pyridyl)methylsulfinyl]benzimidazole compound or salt thereof having antiulcer activity; (b): an aqueous solvent added with no nonaqueous solvent. The injection of the present invention is void of the necessity to lower pH so as to preve nt hemolysis and focal irritation, and to add a nonaqueous solvent to an aqueous solvent for dissolution so as to prevent concomitant degradation of dissolution property. Accordingly, the injection of the present invention can secure solubility sufficient for formulation into preparation and safety for the human body.