| 摘要 |
The invention relates to a method for the synthesis of cyclic peptides or peptidomimetics by means of sequential nucleophile substitutions on polyhalogenated aromatics. The method comprises the following steps: (i) A linear peptide or peptidomimetic with a free nucleophile functionality is reacted with the aromatic in the sense of a simple nucleophile aromatic substitution, whereby the nucleophile functionality is an alcohol, thiol or amine. (ii) The protective group of an additional nucleophile functionality is selectively split at the same peptide or peptidomimetic, whereby the released nucleophile functionality is an alcohol, thiol or amine and (iii) cyclisation is carried out by adding a tertiary amine or another base, whereby cyclisation is carried out by means of nucleophile aromatic substitution of an additional halogen atom of the halogen aromatic by the released nucleophile functionality, said halogen aromatic being bound to the peptide. |
