发明名称 |
Crystal structures of domains of receptor protein tyrosine kinases and their ligands |
摘要 |
The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity. |
申请公布号 |
AU7087000(A) |
申请公布日期 |
2001.03.26 |
申请号 |
AU20000070870 |
申请日期 |
2000.08.30 |
申请人 |
NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
JOSEPH SCHLESSINGER;STEVAN B. HUBBARD;MOOSA MOHAMMADI |
分类号 |
G01N33/50;C07K14/71;C12N9/12;C12Q1/02;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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