METHODS OF USING A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS III HAPLOTYPE TO DIAGNOSE CROHN'S DISEASE
摘要
<p>The present invention provides a method of diagnosing or predicting susceptibility to an autoimmune disease in an individual by determining the presence or absence in the individual of a 2-2-4 haplotype at the Notch4, HSP70-HOM and D6S273 loci, where the presence of the haplotype diagnoses or predicts susceptibility to the autoimmune disease. The methods of the invention can be particularly useful for diagnosing or predicting susceptibility to Crohn's disease, rheumatoid arthritis or type I diabetes mellitus. In a preferred embodiment, a method of the invention is used to diagnose or predict susceptibility to Crohn's disease in an individual of Ashkenazi Jewish ethnicity.</p>
申请公布号
WO0120036(A2)
申请公布日期
2001.03.22
申请号
WO2000US25112
申请日期
2000.09.13
申请人
CEDARS-SINAI MEDICAL CENTER;TAYLOR, KENT, D.;ROTTER, JEROME, I.;YANG, HUIYING