发明名称 |
TRANSDERMAL ADMINISTRATION OF N-(2,5-DISUBSTITUTED PHENYL)-N'-(3-SUBSTITUTED PHENYL)-N'-METHYL GUANIDINES |
摘要 |
Composition of matter for application to a body surface or membrane to administer a N-(2,5-Disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidine by permeation through the body surface or membrane, the composition comprising the guanidine compound to be administered, at a therapeutically effective rate, optionally in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices and methods for the transdermal administration of a guanidine for the prevention of neuropathic pain, neuropsychological deficits resulting from cardiac surgery (CABG), and other neurological disorders.
|
申请公布号 |
WO0119352(A1) |
申请公布日期 |
2001.03.22 |
申请号 |
WO2000US24682 |
申请日期 |
2000.09.08 |
申请人 |
ALZA CORPORATION |
发明人 |
VAN OSDOL, WILLIAM, W.;GALE, ROBERT, M.;BRANDWEIN, DAVID, H.;PADMANABHAN, RAMA;SUNRAM, JOAN |
分类号 |
A61K9/70;A61K31/155;(IPC1-7):A61K9/70 |
主分类号 |
A61K9/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|