发明名称 |
INDOLE-CONTAINING AND COMBRETASTATIN-RELATED ANTI-MITOTIC AND ANTI-TUBULIN POLYMERIZATION AGENTS |
摘要 |
Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting and destruction chemotherapeutic agents or to have anti-angiogenesis activity resulting in the selective prevention and/or destruction of tumor cell vasculature.
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申请公布号 |
WO0119794(A2) |
申请公布日期 |
2001.03.22 |
申请号 |
WO2000US25408 |
申请日期 |
2000.09.15 |
申请人 |
BAYLOR UNIVERSITY;PINNEY, KEVIN, G.;WANG, FENG;DEL PILAR MEJIA, MARIA |
发明人 |
PINNEY, KEVIN, G.;WANG, FENG;DEL PILAR MEJIA, MARIA |
分类号 |
A61K31/404;A61K31/661;A61P35/00;A61P35/02;A61P43/00;C07D209/12;C07D209/14;C07F9/24;C07F9/572;(IPC1-7):C07D209/00 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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