PROSTAGLANDIN DERIVATIVES

摘要

Prostaglandin derivatives of general formula (I), pharmaceutically acceptable salts thereof, or hydrates of both: [wherein X is alpha a- or beta -substituent halogeno; Y is ethylene, vinylene, or ethynylene; A is O(CH2)n, S(O)p(CH2)n, O(CH2)qO(CH2)r, O(CH2)qS(O)p(CH2)r, S(O)p(CH2)qS(O)p(CH2)r, or S(O)p(CH2)qO(CH2)r (wherein n is an integer of 1 to 5; p is 0, 1 or 2; q is an integer of 1 to 3; and r is 0 or 1); R<1> is C3-10 cycloalkyl, C1-4 alkyl C3-10 cycloalkyl, C3-10 cycloalkyl C1-4 alkyl, C5-10 alkyl, C5-10 alkenyl, C5-10 alkynyl, or a bridged cyclic hydrocarbon group; R<2> is H, C1-10 alkyl, or C3-10 cycloalkyl; and m is 0, 1 or 2]. These compounds are novel and exhibit excellent prostaglandin D2-like agonism and a sleep-inducing effect.