COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PATHOGENIC BACTERIAL INFECTION BASED ON THE ESSENTIAL ROLE OF DNA METHYLATION IN BACTERIAL VIRULENCE
摘要
The present invention is directed towards vaccine compositions containing pathogenic bacteria such as Salmonella having non-reverting genetic mutations which alter activity of DNA adenine methylase (Dam) and methods using these compositions to elicit an immune response. The invention also provides methods for preparing vaccines as well as screening methods to identify agents which may have anti-bacterial activity.
申请公布号
WO0045840(A8)
申请公布日期
2001.03.22
申请号
WO2000US02866
申请日期
2000.02.02
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MAHAN, MICHAEL, J.;HEITHOFF, DOUGLAS, M.;LOW, DAVID, A.;SINSHEIMER, ROBERT, L.
发明人
MAHAN, MICHAEL, J.;HEITHOFF, DOUGLAS, M.;LOW, DAVID, A.;SINSHEIMER, ROBERT, L.