发明名称 |
MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) |
摘要 |
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula (1) are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7 are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
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申请公布号 |
WO0119830(A1) |
申请公布日期 |
2001.03.22 |
申请号 |
WO2000DK00502 |
申请日期 |
2000.09.11 |
申请人 |
NOVO NORDISK A/S;ONTOGEN CORPORATION |
发明人 |
ANDERSEN, HENRIK, SUNE;HANSEN, THOMAS, KRUSE;LAU, JESPER;MOELLER, NIELS, PETER, HUNDAHL;OLSEN, OLE, HVILSTED;AXE, FRANK, URBAN;GE, YU;HOLSWORTH, DANIEL, DALE;JONES, TODD, KEVIN;JUDGE, LUKE, MILBURN;RIPKA, WILIAM, CHARLES;SHAPIRA, BARRY, ZVI;UYEDA, ROY, TERUYUKI |
分类号 |
A61K31/337;A61K31/427;A61K31/436;A61K31/4365;A61K31/4439;A61K31/4709;A61K31/517;A61K31/536;A61K45/06;A61P3/00;A61P3/04;A61P3/10;A61P5/00;A61P5/02;A61P5/06;A61P7/00;A61P17/00;A61P17/06;A61P19/00;A61P19/10;A61P25/00;A61P25/18;A61P25/28;A61P31/00;A61P35/00;A61P37/00;A61P37/02;A61P37/08;A61P43/00;C07D495/04;(IPC1-7):C07D495/04;C07D491/04;A61K31/435 |
主分类号 |
A61K31/337 |
代理机构 |
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