发明名称 |
FORMULATIONS FOR TREATING OR PREVENTING MUCOSITIS |
摘要 |
Mucositis is treated and/or prevented by administrating to a patient a formulation comprising a tetracycline that is poorly absorbed from the gastr o- intestinal tract. The tetracycline may be in the form of a pharmaceutically acceptable salt or a base. The formulations may optionally also contain an antifungal agent to prevent fungal overgrowth due to reduction in the normal oral flora by the tetracycline. Such compositions have the advantage of treating the entire gastro-intestinal tract since the active ingredient is n ot removed from the tract via absorption. Further, such compositions minimize systemic exposure and accompanying side effects.
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申请公布号 |
CA2381203(A1) |
申请公布日期 |
2001.03.22 |
申请号 |
CA20002381203 |
申请日期 |
2000.09.14 |
申请人 |
ORAPHARMA, INC. |
发明人 |
COMISKEY, STEPHEN J.;LAWTER, JAMES RONALD |
分类号 |
A61K9/06;A61K9/00;A61K9/12;A61K9/16;A61K9/20;A61K9/50;A61K31/196;A61K31/65;A61K47/36;A61P1/02;A61P1/04;A61P29/00;(IPC1-7):A61K31/166;A61P17/00 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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