METHODS AND COMPOSITIONS UTILIZING RAD51

摘要

Herein methods are provided for determining the distribution of Rad51 foci i n a first tissue type of a first individual, and then comparing the distributi on to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 foci. Preferred disease states include cancer and disease states associated with apoptosis. Also provided herein ar e methods for screening for modulators of Rad51 or homologues thereof and methods of using modulators of Rad51.