发明名称 |
Novel cephalotaxane derivatives and process for their preparation. |
摘要 |
The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed. |
申请公布号 |
ZA200005018(B) |
申请公布日期 |
2001.03.22 |
申请号 |
ZA20000005018 |
申请日期 |
2000.09.20 |
申请人 |
ONCOPHARM CORPORATION |
发明人 |
JEAN-PIERRE ROBIN;JULIE ROBIN;SYLVIE CAVOLEAU;LUDOVIC CHAUVIAT;SANDRA CHARBONNEL |
分类号 |
A61K31/55;A61P35/00;C07C57/13;C07C59/42;C07C59/48;C07C69/732;C07D303/48;C07D305/08;C07D309/08;C07D453/04;C07D487/04;C07D491/147;C07D491/20;C07D493/10 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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