| 摘要 |
<p>DNA binding compounds which are dimers of netropsin or netropsin analogs, linked by a polycyclic linker group, are disclosed. The binding compounds have the structure B-L-B', where B and B' independently have the structure (I) in which A is amidinyl (-C(NH2)=NH) or -CH2NRR', where R and R' are independently hydrogen or lower alkyl, or together form a 5- to 7-member heterocyclic ring whose ring atoms are selected from the group consisting of carbon, nitrogen, oxygen and sulfur, and include at least 3 carbon atoms, and n is 1-6. L is a fused polycyclic ring system containing at least one aromatic ring, and B and B' are linked to different rings of said ring system, such that the shortest path between B and B' comprises a sequence of at least three bonds within the ring system, when the groups are attached to adjacent (fused) rings, or at least five bonds within the ring system, when the groups are attached to non-adjacent rings.</p> |
