AGENTS FOR TREATING HUMAN DISEASES, ESPECIALLY FOR TREATING TUMORS SUCH AS COLONIC CANCERS AND MELANOMAS OR FOR REGENERATING TISSUE AND PROMOTING HAIR GROWTH

摘要

The invention relates to agents for treating human diseases which are based on substances that specifically influence the binding of .beta.-catenin on LEF- 1/TCF- transcription factors, APC or conductin/axin. The invention particularly relates to the identification and use of hydrophobic pockets on the molecular surface in the proximity of the essential binding points for t he binding partners of .szlig.-catenin with the aim of optimizing these substances. The invention also relates to the use of the substances, preferably for treating tumors such as colonic cancers and melanomas or for regenerating tissue and promoting hair growth.