AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS

摘要

The present invention provides an amino compound represented by Formula: wherein X is CH2NH or CONH, Y is CH2NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R<4>)R<5>, CH2CH(R<4>)R<5> or an alkoxycarbonyl group, R<1> is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R<2> and R<3> are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R<4> and R<5> are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.