发明名称 |
Antisense inhibition of Fas mediated signaling |
摘要 |
Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.
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申请公布号 |
US6204055(B1) |
申请公布日期 |
2001.03.20 |
申请号 |
US19990290640 |
申请日期 |
1999.04.12 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
DEAN NICHOLAS M.;MARCUSSON ERIC G. |
分类号 |
C12N15/09;A61K31/7088;A61K31/7115;A61K31/712;A61K31/7125;A61K38/00;A61K48/00;A61P1/16;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C12N15/113;(IPC1-7):C07H21/04;C12N15/85;C12N15/86 |
主分类号 |
C12N15/09 |
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