| 摘要 |
The invention provides isolated nucleic acid molecules, designated ABCB12 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCB12 transported nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ABCB12 transported gene has been introduced or disrupted. The invention still further provides isolated ABCB12 transporter proteins, fusion proteins, antigenic peptides, anti-ABCB12 transporter antibodies, and screening assays for ABCB12 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided. |
