发明名称 |
HUMAN INTERLEUKIN-2 MUTANT WHICH ACTIVATES PREFERABLY T-CELLS AS COMPARED WITH NATURAL KILLER CELLS, PHARMACEUTICAL COMPOSITION, POLYNUCLEOTIDE, VECTOR, PROCARIOTIC CELL, A METHOD FOR THE STIMULATION OF IMMUNE SYSTEM |
摘要 |
The invention concerns the human interleukin -2 mutant numerated according to the wild type of interleukin -2, which has an aminoacid substitution in one or two positions with 20, 88 and 126, said mutants activate preferably T-cells as compared with natural killer cells and have smaller toxicity. The invention concerns also polynucleotide coding said interleukin -2 mutant, vector and cell which include said polynucleotide, pharmaceutical composition and a method for stimulation of immune system.
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申请公布号 |
UA73719(C2) |
申请公布日期 |
2001.03.15 |
申请号 |
UA20000127206 |
申请日期 |
1999.05.13 |
申请人 |
BAYER CORPORATION |
发明人 |
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分类号 |
G01N33/50;A61K38/00;A61K38/20;A61P35/00;C07K14/55;C12N15/09;C12N15/26;C12Q1/02;G01N33/15;(IPC1-7):C07K14/55 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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