| 摘要 |
<p>An industrially advantageous process for producing optically active 4-amino-2-methylbutan-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutan-1-ol is treated with an optically active organic acid. The diastereomeric salt thus formed is crystallized out and subjected to solid-liquid separation to give optically active 4-amino-2-methylbutan-1-ol. This diastereomeric salt of optically active 4-amino-2-methylbutan-1-ol with an optically resolving agent is desalted by bringing into contact with a solvent and an alkali and subjecting to solid-liquid separation, thereby recovering the optically active 4-amino-2-methylbutan-1-ol from the filtrate. Further, the filtration residue containing the alkali salt of the optical resolving agent obtained by the solid-liquid separation is brought into contact with a solvent and an acid. Then the optical resolving agent thus crystallized out is subjected to solid-liquid separation and recovered.</p> |
