| 摘要 |
<p>The present invention relates to a method for the diagnosis of a disease associated with protein accumulation in intranuclear inclusions in a cell of a patient. The method comprises obtaining a sample from the patient; and determining a presence of the protein accumulation in the intranuclear inclusions, wherein the protein accumulation in the intranuclear inclusions is indicative of a disease associated therewith. The invention also relates to a method for the screening of agents which can module one of (a) polyamino acid stretch-containing protein expression; (b) accumulation of polyamino acid stretch-containing proteins in intranuclear inclusions; and (c) toxicity of polyamino acid stretch-containing proteins to cells, which comprises incubating a cell which expresses a polyamino acid stretch-containing protein, associated with a disease or condition in an animal, with a compound; and assessing one of (a) to (c); whereby a modulator is selected when the agent significantly modulates one of the expression, accumulation and toxicity, as compared to a control agent.</p> |
