NANOPARTICULATE COMPOSITIONS COMPRISING AMORPHOUS CYCLOSPORINE AND METHODS OF MAKING AND USING SUCH COMPOSITIONS
摘要
Nanoparticulate amorphous cyclosporine formulations, and nanoparticulate cyclosporine formulations comprising a mixture of amorphous and crystalline cyclosporine, having effective average particle sizes of less than about 2000 nm are described. The compositions exhibit increased bioavailability and increased consistency of bioavailability as compared to prior macro-sized cyclosporine and formulations. Methods of making and using the compositions are also described.
申请公布号
WO0117546(A1)
申请公布日期
2001.03.15
申请号
WO2000US24505
申请日期
2000.09.07
申请人
ELAN PHARMA INTERNATIONAL LTD.;BOSCH, H., WILLIAM;OSTRANDER, KEVIN, D.;HOVEY, DOUGLAS, C.
发明人
BOSCH, H., WILLIAM;OSTRANDER, KEVIN, D.;HOVEY, DOUGLAS, C.