| 摘要 |
PURPOSE: Disclosed is a new DNA structure for tissue-specific expression of a blood coagulation factor consisting of the DNA encoding the amino acid sequence of the blood coagulation factor and the DNA encoding a promotor specific to the expression in hematopoietic cells, and useful for the genetic treatment of hemophilia B or the like. CONSTITUTION: The new DNA structure for tissue-specific expression of a blood coagulation factor consists of the DNA encoding the amino acid sequence of the blood coagulation factor and the DNA encoding a promotor specific to the expression in hematopoietic cells, and it is useful for the genetic treatment of hemophilia B or the like. The DNA structure is obtained by inserting an promotor which consists of the DNA encoding the amino acid sequence of a blood coagulation factor consisting of the cDNA encoding blood coagulation IX factor or the like, and the DNA encoding human platelet glycoprotein IIb(GPIIb) or the like, and which is specific to the expression in hematopoietic cells, into an appropriate expression vector.
|
