NON-AROMATIC ESTROGENIC STEROIDS WITH A HYDROCARBON SUBSTITUENT IN POSITION 11

摘要

Disclosed are novel, selective estrogens type having a steroid skeleton with a non-aromatic A-ring and a free or capped hydroxyl group at carbon atom No. 3. The estrogens satisfy general formula (I), in which R<1> is H, (C1-C3)alkyl or (C2-C3)acyl; R<2> is H, alpha -(C1-C4)alkyl, alpha -(C2-C4)alkenyl or alpha -(C2-C4)alkynyl; R<3> is H or (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl, each at location 15 or 16 of the steroid skeleton; R<4> is H or (C1-C5)alkyl, (C2-C5)alkenyl or (C2-C5)alkynyl, each optionally substituted with halogen; preferred is ethynyl; R<5> is H, (C1-C3)alkyl or (C2-C3)acyl; R<6> is (C1-C5)alkyl, (C2-C5)alkenyl, (C2-C5)alkynyl or (C1-C5)alkylidene, each optionally substituted with halogen or (C1-C3)alkyloxy; dotted bonds represent optional double bonds.