发明名称 |
SUBSTITUTED N-PHENYL 2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANAMIDE DERIVATIVES WHICH ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY |
摘要 |
A compound of formula (I) wherein: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 is as defined within; R3 is as defined within; and R4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, metho ds and processes for preparation of compounds of formula (I) are detailed.</SDO AB>
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申请公布号 |
CA2381581(A1) |
申请公布日期 |
2001.03.15 |
申请号 |
CA20002381581 |
申请日期 |
2000.08.30 |
申请人 |
ASTRAZENECA AB |
发明人 |
BUTLIN, ROGER JOHN;BLOCK, MICHAEL HOWARD;BURROWS, JEREMY NICHOLAS;NOWAK, THORSTEN;PEASE, JANET ELIZABETH |
分类号 |
C07D295/12;A61K31/167;A61K31/397;A61K31/40;A61K31/44;A61K31/4402;A61K31/495;A61K31/4965;A61K31/5375;A61K31/54;A61P3/06;A61P3/10;A61P9/00;A61P9/04;A61P9/08;A61P9/10;A61P25/28;A61P43/00;C07C315/02;C07C315/04;C07C317/40;C07C317/42;C07C317/44;C07C317/50;C07C323/65;C07D205/04;C07D207/12;C07D213/72;C07D213/73;C07D295/135;C07D295/18;C07D295/185;C07D295/26;(IPC1-7):C07C317/42 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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地址 |
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