SUBSTITUTED CYCLOPENTENES, THEIR PREPARATION AND THEIR USE FOR CHIRAL SCAFFOLDS

摘要

3,4-Disubstituted-1-cyclopentene compounds, in substantially enantiopure form, have the relative stereochemistry according to formula (1A) or (1B) including the opposite enantiomers thereof, wherein R<1> is either COOX, wherein X is alkyl, H or a salt-forming cation, or CH2OH, wherein the hydroxyl group is optionally protected; R<2> is H or a protecting group; R<3> is H or alkyl; and R<4> is H, alkoxy, alkyl, aryl or aralkyl; or, in the case of formula 1A, R<2> and R<4> are linked to form an oxazolidinone ring. These compounds can be used to prepare a series of complementary stereochemically varied cyclopentane scaffolds.