METHOD FOR IDENTIFYING MODULATORS OF DAF-16

摘要

The invention comprises methods for identifying agents that can activate C. elegans DAF-16 and human homologs thereof, or their corresponding genes, whereby cytoprotective effects in cells may be induced. Such cytoprotective effects can result in enhanced environmental stress resistance, increased life span and improved late life vigor without significant inhibition of insulin-signaling pathways. The invention also comprises the therapeutic agents identified and methods of treatment using the agents.