| 摘要 |
PURPOSE: A (poly)thiaalkyne (acid) type compound is provided, which has an activity related to the transactivation of a PPAR type receptor, especially a PPAR-α-subtype receptor and is preferably useful for treating inflammatory diseases such as rheumatic arteritis, lupus and psoriasis. CONSTITUTION: A compound of the formula I: R1-Y-CH2-C equiv. C-CH2-S-CH2-R2 {Y is S(0)t £(t) is 0 to 2|, CH2, C equiv. C or C=C; R1 is a (halogenated) 1 to 18C alkyl, a 1 to 18C alkenyl, a 1 to 18C alkynyl or the like; R2 is tetrazolyl, nitrile, oxazolinyl or the like} and its derivative. For example, 3,8-dithia-5-hexadecylic acid. The compound of the formula wherein Y is methylene or a triple bond is obtained, for example, by reacting a compound of the formula: R1-X with sodium acetylide and then reacting the obtained compound of the formula: R1-C equiv. C-H as a starting raw material. When added to a cosmetic composition, the compound is preferably added in a concentration of 0.0001 to 3 wt.%.
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