| 摘要 |
A process for preparing a 3-dihalobenzyl-2,4-quinazolinedione derivative represented by the formula (V):(whereinX1, X2, X3 are independently a halogen atom, andA is an alkylene group),which comprises:reacting a dihalobenzyl derivative represented by the formula (III):(whereinX2 and X3 are each as defined above, andL is an acid residue)with a 2,4-quinazolinedione derivative having a carboxyalkyl group represented by the formula (I):(wherein X1 and A are each as defined above)to selectively substitute a hydrogen atom of an imino group at the 3-position of the derivative (1).The above process enables the efficient preparation of the compounds of the above formula (V) useful as inhibitors against aldose reductases, makes it possible to secure the safety and hygiene of workers, and can facilitate waste disposal to reduce the expenses, thus being industrially extremely advantageous.
|
