| 摘要 |
A process for making a 1,3,5,7-tetraalkanoyl-1,3,5,7-tetraazacyclooctane comprises the steps of:(a) reacting a compound having the formulawherein R is straight chain or branched alkyl having 1-5 carbon atoms, with an alkanoic acid anhydride having the formula (RCO)2O, where R is as defined above, thereby producing a compound having the formula:wherein R is as defined above; and(b) reacting the compound having the formula (II) with the alkanoic acid anhydride in the presence of water and a catalytic amount of at least one transition metal oxide, thereby producing a compound having the formulawhere R is as defined above.
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