发明名称 |
Ttp-related zinc finger domains and methods of use |
摘要 |
The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA moleculeencoding TNF- alpha , and methods of inhibiting the degradation of an mRNA molecule encoding GM-CSF. Also provided are methods for identifying compounds that regulate the destruction of mRNA moleculescontaining AREs. |
申请公布号 |
AU6638800(A) |
申请公布日期 |
2001.03.13 |
申请号 |
AU20000066388 |
申请日期 |
2000.08.14 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
PERRY J. BLACKSHEAR;WI S. LAI;ESTER CARBALLO-JANE |
分类号 |
A61K38/17;A61K48/00;A61P7/00;C07K14/47;C12N15/12;C12N15/63 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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