| 摘要 |
The present invention is directed to a method of inducing angiogenesis in a tissue in need of angiogenesis, comprising providing the tissue in need of angiogenesis with an angiogenically effective amount of a recombinant c-fos induced growth factor/vascular endothelial growth factor D (Figf/Vegf-D), which is secreted factor of the VEGF family which binds to the vessel and lymphatic receptors VEGFR-2 and VEGFR-3 (VEGF-D). In another aspect, the present invention is directed to a method of inducing angiogenesis in an area in need of angiogenesis in a mammal comprising administering to said area in need of angiogenesis an angiogenically effective amount VEGF-D. The VEGF-D is provided or administered in solution of slow release form. |
