发明名称 |
Serpin enzyme complex receptor-mediated gene transfer |
摘要 |
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
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申请公布号 |
US6200801(B1) |
申请公布日期 |
2001.03.13 |
申请号 |
US19980217847 |
申请日期 |
1998.12.21 |
申请人 |
CASE WESTERN RESERVE UNIVERSITY |
发明人 |
FERKOL, JR. THOMAS W.;DAVIS PAMELA B.;ZIADY ASSEM-GALAL |
分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K35/76;A61K47/48;A61K48/00;C07H21/00;C07K14/47;C07K14/705;C07K16/18;C07K19/00;C12N5/10;C12N9/64;C12N15/87;(IPC1-7):C12N15/63;C07K5/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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