发明名称 |
Enhanced yield of podophyllotoxin from natural products through in situ conversion methods |
摘要 |
Enhanced recovery of podophyllotoxin from biological sources is achieved through disruption or permeabilization of the physical integrity of cells and tissues in the presence of sufficient moisture so as to allow endogenous enzymes to convert podophyllotoxin glucosides to podophyllotoxin. Extraction of the podophyllotoxin from the plant material is then achieved by use of an organic solvent. Podophyllotoxin is used as an intermediate in the production of the antitumor agent etoposide and its analogues. |
申请公布号 |
AU7881300(A) |
申请公布日期 |
2001.03.13 |
申请号 |
AU20000078813 |
申请日期 |
2000.08.16 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY O;THE UNIVERSITY OF MISSISSIPPI |
发明人 |
CAMILO CANEL;FRANCK E. DAYAN;RITA M. MORAES;CHARLES L. BURANDT |
分类号 |
A61K36/29 |
主分类号 |
A61K36/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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