发明名称 Method of screening for compounds that dissolve paired helical filaments
摘要 The invention relates to epitopes of the protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
申请公布号 US6200768(B1) 申请公布日期 2001.03.13
申请号 US19940244603 申请日期 1994.11.28
申请人 MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN 发明人 MANDELKOW EVA-MARIA;MANDELKOW ECKHARD;LICHTENBERG-KRAAG BIRGIT;BIERNAT JACEK;DREWES GERARD;STEINER BARBARA
分类号 C12N15/02;A61K38/00;A61K38/45;A61K38/46;A61K38/55;A61K39/00;A61K39/395;A61P25/28;C07K1/18;C07K7/06;C07K7/08;C07K14/47;C07K14/81;C07K16/00;C07K16/18;C07K16/40;C12N5/10;C12N9/12;C12N9/16;C12N15/09;C12N15/12;C12N15/16;C12P21/02;C12P21/08;C12Q1/68;G01N33/50;G01N33/53;G01N33/573;G01N33/68;(IPC1-7):C12Q1/48 主分类号 C12N15/02
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