| 摘要 |
PROBLEM TO BE SOLVED: To obtain a skin preparation for external use useful for improving the chapped skin caused by an allergic reaction, an extraneous fungus, drying or the like by making the preparation include a specific mono-cis- alkenecarboxylic acid and specified ceramides in specific amounts. SOLUTION: This preparation for external use is obtained by including (A) 1-10 wt.% of cis-6-hexadecenoic acid and (B) 0.1-10 wt.% of ceramides or a substance having a ceramide analogous structure. The ingredient A is especially preferably formulated in an amount of 1-5 wt.% and the ingredient B is especially preferably formulated in an amount of 0.1-5 wt.%. The weight ratio of the ingredients A:B is preferably (100:1) to (1:10), especially preferably (10:1) to (1:10). The pH of the preparation for external use is preferably 2-6.9, especially preferably 3-6.5 for application to the skin showing atopic dermatitis. The ingredient A can be prepared by a well-known metathetic reaction or a method of using a microorganism but may be extracted from Thunbergia alata which is a liana for use. A natural ceramide, a sphingosine derivative and the like are cited as the ingredient B.
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