发明名称 |
CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS |
摘要 |
This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.
|
申请公布号 |
US2007286801(A1) |
申请公布日期 |
2007.12.13 |
申请号 |
US20030341316 |
申请日期 |
2003.01.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
TOYOKUNI TATSUSHI;SATYAMURTHY NAGICHETTIAR;HERSCHMAN HARVEY R.;PHELPS MICHAEL E.;BARRIO JORGE R. |
分类号 |
A61K51/00;A61K31/42;A61K49/10;A61K51/04;C07D261/06 |
主分类号 |
A61K51/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|