CELL-SPECIFIC AND/OR TUMOR-SPECIFIC PROMOTER RETARGETING OF HERPES GAMMA 34.5 GENE EXPRESSION

摘要

The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populatio ns of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and/or cell-specific promoters to drive expression of the herpes .gamma.34.5 gene.