MATERIALS AND METHODS FOR INHIBITION OF IgE PRODUCTION

摘要

The subject invention concerns novel methods and materials for treating patients afflicted with allergic conditions, such as allergic rhinitis, atopic dermatitis, bronchial asthma and food allergy. The method of the subject invention comprises administering interferon tau (IFN tau ) or a chimeric IFN (ovine IFN tau (1-27)/human IFN alpha D (28-166)) to a person afflicted with an allergic condition. When administered, IFN tau and chimeric IFN suppress the production of IgE antibodies without toxic side effects. The subject invention also concerns chimeric ovine/human IFNs which can be used in the methods of the invention.