The present application identifies the NS4A binding site present on NS2/3 as a target site for inhibiting NS2/3 protease activity. Methods inhibiting NS2/3 activity by targeting the identified target site are described along with examples of compounds useful in such methods and guidance for obtaining additional useful compounds. Such compounds and methods are preferably employed to inhibit HCV replication.
申请公布号
WO0116379(A1)
申请公布日期
2001.03.08
申请号
WO2000US23444
申请日期
2000.08.25
申请人
MERCK & CO., INC.;DARKE, PAUL, L.;JACOBS, AMANDA, R.;KUO, LAWRENCE, C.
发明人
DARKE, PAUL, L.;JACOBS, AMANDA, R.;KUO, LAWRENCE, C.